Stewie Griffin Stewart Gilligan "Stewie" Griffin is a fictional character from the animated television series Family Guy. Once obsessed with violence and matricide, Stewie (voiced by Seth MacFarlane) is the youngest child of Peter and Lois Griffin, and the brother of Chris and Meg. Over the duration of the series, he has also come to have a very close friendship with the family's anthropomorphic dog, Brian.
Brian Griffin is a fictional character from the animated television series Family Guy. An anthropomorphic dog, voiced by Seth MacFarlane, he is one of the show's main characters and a member of the Griffin family. He primarily works in the series as a struggling writer, attempting essays, novels, screenplays and newspaper articles.